Singapore: A team of scientists from Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has uncovered new molecular interactions involved in the development of cervical cancer. Proteins EDD1 and TIP60 were found to interact with the Human Papilloma Virus (HPV), which causes cervical cancer in humans. EDD1 is an E3 ubiquitin ligase involved in degrading cellular proteins, while TIP60 act as a tumor suppressor protein, and can both be found in the human body.
The research team, comprising Assistant Professor Sudhakar Jha, Dr Vanitha K. Subbaiah and Mr Zhang Yanzhou, found that HPV E6 oncogene interacts with EDD1 to destabilise the TIP60 protein, thereby resulting in an increased tumorigenesis. In support of this finding, experiments also revealed that an increase in cellular TIP60 levels could inhibit cancer cell growth.
Previous studies have implicated the roles of both EDD1 and TIP60 in cancer progression, however their roles in viral-mediated cancers have not been well-explored. Notably, this study is one the few which explores the functional role of TIP60 in viral-mediated cancers. It is also the first to suggest EDD1 as a novel interacting partner of TIP60, a finding which advances the understanding of how this pathway could contribute to cancer progression not only in cervical cancer, but also in many other cancer types such as breast and ovarian cancer.
Oncoviruses (cancer-causing viruses) are said to account for about 12 percent of new cancer cases annually. Cervical cancer, which is the cancer of the cervix, accounts for about 8 percent of all cancer cases worldwide and is the fourth most common cause of cancer and deaths from cancer in women. Infections with cancer-causing viruses such as HPV are a major health burden worldwide, and contribute significantly to patient mortality. Availability of prophylactic vaccines hold promises in the prevention of the disease, but unfortunately does not help already-infected patients.
