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Cobra Biologics Completes Key CombiGene Milestone

Increase font size  Decrease font size Date:2020-04-07   Views:376

Cobra Biologics, an international CDMO, has successfully produced and delivered the first DNA plasmid required to produce CombiGene’s gene therapy drug candidate CG01, for the treatment of drug-resistant focal epilepsy.
 
For the vital compounds of CG01, Cobra Biologics has finalized production and delivery of the first of three key plasmids, enabling the downstream processes to be initiated. In addition to these plasmids, a specific type of cell, which Cobra is also producing, acting as the ‘factory’ to produce the CG01 compound is necessary. 
 
After the production of the plasmids for CG01, and the successful transfer of the production process from the Cell and Gene Therapy Catapult to Cobra, an engineering run will be initiated, whereby the entire production process will be tested. Material from this engineering run will be used in the toxicity and biodistribution tests that are planned.
 
Karin Agerman, Chief Research and Development Officer, CombiGene: “The successful production and delivery of the first of three vital plasmids is a major milestone in our collaboration with Cobra Biologics, and in the CG01 project. We look forward to a continued successful partnership working together to bring this treatment to epilepsy patients.”
 
Peter Coleman, Chief Executive, Cobra Biologics: “This is an exciting step in the progression of the CG01 project, in which we are proud to be taking such a key role. Following the announcement of this collaboration in October last year, we have demonstrated the strength in our experience and capabilities to respond quickly, yet accurately, to support CombiGene in bringing CG01 closer to market, sooner.”

 

 
 
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