Original
Quick Detail:
Arimidex is the aromatase inhibitor of choice. Arimidex's mechanism of action - blocking conversion of aromatizable steroids to estrogen - is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) or (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others.
De
Alias: Arimidex
CAS No: 120511-73-1
MF: C17H19N5
MW: 293.37
Purity: 98%
Appearance: white powder.
Applications:
Steroids Hormone Arimidex powders/CAS No: 120511-73-1
The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.
Items
Standard
Results
De
White crystalline powder
Complies
Identification
IR
HPLC
Reactive
Conform with standard IR
Conform with standard HPLC
Conform
Solubility
Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrile
Complies
Total Impurity
max.0.5%
0.18%
Total Unspecified Impurity
max. 0.2%
0.08%
Individual unspecified impurlty
max. 0.1%
0.05%
Related compound B
max. 0.2%
0.07%
Related compound C
max. 0.2%
0.04%
Related compound D
max. 0.1%
0.05%
Related compound E
max. 0.1%
0.06%
Limit of cyclohexane
max. 0.08%
ND
Limit of ethylacetate
max. 0.1%
0.07%
Melting point
81.0~84.0°C
82.5~83.2°C
Water
max. 0.3%
0.21%
Residue on ignition
max. 0.1%
0.07%
Heavy Metals
max.0.001%
Complies
Assay(HPLC)
98.0%~102.0%
99.8%
Storage
Cool and dry
Conclusion
It complies to USP32 .
