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Octreotide Acetate

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CAS: Octreotide Acetate 
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Updated on: 2015-06-11
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Description

Apperance:white to off-white, amorphous powder of low density
 
Solubility: Soluble in water and 1% acetic acid at a concentration of ≥1 mg/ml to give a clear, colorless solution

 

Identity: Monoisotopic Mass: 1018.4 ±1 m.u.
(by Mass Special Analysis)

 

Identity                          

(by Mass Special Analysis)        

                  Thr  0.85 to 1.15

                  Cys 1.3 to 2.1*

                  Phe 1.7 to 2.3

                  Lys 1.3 to 2.1**

                  Trp Present    

*Hydrolyze without phenol to recover Cys            

**Thr-ol co-elustes with Lys    
 
Identity:     
    Coelutes with reference standard
       System I (0.1% TFA/Acetonitrile)
       Gradient=15-40% in 25 minutes
       System II (0.1M teap, pH 2.3/Acetonitrile
       Gradient=10-35% in 25 minutes
 
Peptide purity:  ≥98%
By Analytical HPLC
 
Related substance ≤2% total
 
Water (karl Fisher) ≤ 10%
 
Specific Rotation    -17o to -21o           [α]D~20 c=0.5, 1% acetic acid)
 
pH: 5-7
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