Multi-stage countercurrent extraction unit continuously

S my company according to the principle of traditional Chinese medicine production technology mature the traditional craft combined with modern science and technology development of patent products "multi-stage spiral continuous countercurrent extraction unit", is a kind of effective ingredients of natural products, such as traditional Chinese medicine) extraction of a new dynamic extraction equipment used natural product extraction of traditional Chinese medicine (TCM) biological pharmaceutical care, food plant pesticide cosmetics RongYe forestry and other industries; Such as extraction of alkaloids, brass, nonsteroidal, quinones and terpenoids and other active ingredients.
 

Technical background and principle

▲While the diffusion and mass transfer equation：Type G for the diffusion of material, t is diffusion time, F diffuse surface on behalf of the medicinal material particle size and surface state, (C1 and C2) as the concentration difference, D for the diffusion coefficient, the delta for solid diffusion layer thickness, therefore, the size of the G value and medicinal materials crushing degree, surface state and diffusion process of concentration, diffusion time and diffusion coefficient is proportional to the relationship, and solvent, temperature, solid drugs between particles and liquid state of fluid mechanics, relative speed is high, due to the friction between the effect, make the diffusion boundary layer thin or updates faster and faster, thus good for accelerating leaching, the diffusion of power, is a concentration difference or a concentration gradient.
▲Bring under the effect of heating and/or ultrasonic and microwave, the multistage continuous countercurrent extraction is to increase the leaching rate, yield and quality, and the effective way of saving energy and reducing consumption. Diffuse out of the process, the completeness of solid-liquid separation per level is very important. Leaching per level, after the completion of medicines in the effective components and effective into the component ratio in the leach liquor has important influence on leaching rate. If per level after leaching, solid-liquid separation is not complete, will affect the ratio (a) a quick rate, the separation is not completely after will cause the level of fresh solvent or solution after just contact herbs had a certain concentration of active ingredients at the next higher level, the solid-liquid equilibrium to leaching direction or rate of increase will be unfavourable. Leaching after the completion of each level, therefore, should let per level of leach liquor and the complete separation of medicinal materials as much as possible.
▲Bring in view of the traditional extraction tank every batch of candy medicine decoction 2-3 times, although the technology mature, but the solid-liquid ratio, concentration difference is small, low yield, high temperature, time is long, adverse to the heat-sensitive active ingredients. A manufacturer USES several sets of extraction tank of the reflux tank group multi-stage counter-current diffuse out of the process, can be limited to improve yield, but still to static intermittent operation, each level, after the completion of leaching out leach liquor for a long time to leaching liquid and solid-liquid separation of crude drugs, both time-consuming and separation is not complete.
▲Bring a jacket heating component and/or spiral of continuous countercurrent extraction device of ultrasonic components relative effect is good, but decorate a form one section slot machine horizontal lined his word fore and aft concatenated, machine slot only driven by the driving mechanism, took the long, axial force, although composed of multiple class concatenated, but the craft level is still the continuous countercurrent extraction, during which there is no solid liquid separation process. The spiral ultrasonic overflow and pot kettle type ultrasonic continuous countercurrent overflow, all transducer through the pipe wall, the tank wall and medium again passed to the material, ultrasonic energy attenuation. And high-power transducer plug-in, direct contact with the material and energy utilization rate is high, the positive cell wall-breaking, some with pump or compressed air circulation, solid-liquid separation between some stepless, in creating and expanding concentration, solid-liquid separation still needs improvement and convenient cleaning.
▲Bring this company produces the multi-stage spiral continuous counter-current diffuse out of the line with the existing technology, this unit has a heating jacket and/or of several vibration with immersion ultrasonic components machine groove parallel to the parallel arrangement, machine slot between auxiliary materials to the client and into the side respectively by the unique lose pressure institutions and infusion institutions into an organic whole, constitute the beginning and the end of the closed operation of indirect connection in parallel, with level of solid-liquid separation between continuous counter-current multistage leaching system. The native components jacket heating (or cooling) type ultrasonic type and both type.
▲Bring in the jacketed heat or ultrasonic cavitation effect, the cell walls of medicinal materials rapid burst, solvent to accelerate the active ingredients of permeability and dissolve cells, continuous countercurrent extraction process is to create and maintain maximum concentration are favorable conditions, to increase the mass transfer driving force, while the dynamic diffuse to spread thin boundary layer and updates faster, thus leaching and mass transfer resistance is reduced, thus improve the overflow rate; Again because of several machine slot by unique to lose pressure between institutions and infusion institutions into an organic whole, so that the level of leaching of the active ingredients of material also is in this level of leach liquor. At all levels, in turn, so, let each stage leaching liquid and medicine completely separate as much as possible, only to soak out the material into the next level, lower level of leaching liquid flow eight or at the next higher level, that is as far as possible let leaching materials into effective shunt people at the next lower level. In this way, can make the primary flow of the active ingredients are sufficiently leaching leaching liquid, the last stage of extrusion machine discharge slag is almost slag containing no active ingredients. If a 70% per level of overflow rate calculation, then the second rate can reach 91%, the third level is 97.3%, the more series, the higher yield, of course also consider eight output ratio.
 

Product structure
▲Bring the match with sealing cover of "U" type cross section machine groove, helix segmented detachable structure, each set filter structure, not only satisfy the material and solvent instead of smooth continuous countercurrent extraction, convenient for observation, operation, management, machine groove can be easily removed, thoroughly clean, leave no dead Angle, clean sanitation, in line with the GMP requirements
▲Bring about mixing and microwave pretreatment points, meet the infiltration process of different physical and chemical properties of different varieties of material requirements. Extraction auxiliary agent can be used both {such as surfactant) and stir, but also by microwave rapid cell wall-breaking method, to accelerate the process of infiltration, increase the leaching efficiency.
▲Bring groove between the screw conveying and extrusion machine (system can realize explosion-proof), by taking over is linked together, form a parallel state, fore and aft of the parallel detour through each section slot machine configuration drive mechanism, length, width and high proportion coordination, improved axial force. Slot by iv has a level difference between connected, grade structure body linkage, ask full solid-liquid separation of multistage continuous countercurrent extraction system.
▲Bring about the end of the class is equipped with strong slag extruding machine, get rid of the disadvantages of the liquid slag.
▲Bring the entire automatic control, the system adopts PLC and programming setting various parameters, if encounter overload, wrong operation and so on can transition protection. Front-rear speed, flow, level, temperature and so on will be documented and can be set up, meet the demand of the production process of all functions and production flexibility.

Schematic diagram