camptothecin(camptothecine)

1. Single impurity: less than 0.5% generally, or <0.1% as required
2.Capacity:300kg/Month
3.Leading natural plant ingredients supplier in China with 16 years’ experience.

3.ISO9001&ISO14001 certified and steady supply

4.Professional R&D team and strong R&D strength.
 

Packing with IATA required carton with 10kg/carton, or as customer required.

Stored in a cool, dry and dark place, shelf life 24 months.

Camptothecin showed remarkable anticancer activity in preliminary clinical trials by inhibiting the DNA enzyme topoisomerase I (topo I). (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.

1. Camptothecin is the natural starting material of Irinotecan HCl.

2. Camptothecin is the natural starting compound of 10-Hydroxycamptothecin.

3. Camptothecin is the natural starting ingredient of 7-Ethyl-10-Hydroxycamptothecin(SN-38).

4. Camptothecin is the natural starting ingredient of Topotecan HCl

5. This compound camptothecin is a featured product for Apoptosis research.

1. Camptotheca acuminata (Camptotheca, Happy tree), a tree native to Hunan ,Guangxi, Sichuan province of China. Camptotheca acuminata used as a cancer treatment in Traditional Chinese Medicine.Generally, the leaves and the fruits of happy tree are applied for the extraction of camptothecin.

2. Nothapodytes pittosporoides(Mappia), a tree wild spread in  Hunan ,Guangxi, Sichuan province of China. The root of the tree is applied for the extraction of campothecin, most of this origin is applied for R&D.