estradiol

Quick Detail:

Product Name: estradiol

Product Name:Estradiol;beta-estradiol-16;Estradiol;estradiol

CAS:50-28-2

EINECS:200-023-8

Molecular Weight:272.38

Molecular Formula:C18H24O2

Appearance:White Crystalline Powder

Usage:Estradiol by estrogen in the treatment of skin absorption agent

Description:

17α-Estradiol is a less feminizing isomer of the potent hormonal estrogen, 17β-estradiol. 17α-Estradiol is an orally active small molecule with conflicting reports of efficacy in preclinical models of degenerative diseases. A number of studies suggest neuroprotective potential in human neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease. Several studies have established an antioxidant effect of 17α-estradiol in humans. 

Applications:

1). 17α-Estradiol is a less feminizing isomer of the potent hormonal estrogen, 17β-estradiol. 17α-Estradiol is an orally active small molecule with conflicting reports of efficacy in preclinical models of degenerative diseases. A number of studies suggest neuroprotective potential in human neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease. Several studies have established an antioxidant effect of 17α-estradiol in humans.

2). The sodium salt of 17α-estradiol 3-sulfate is a minor component (2.5-9.5%) of several widely marketed estrogen hormone replacement products, such as Premarin, that are approved by the U.S. Food and Drug Administration and have been prescribed and studied in women and men for more than 65 years. Most of the more than 100 published reports on the neurological effects of feminizing estrogens found positive responses in at least one measure relating to cognition or prevention and treatment of AD, notwithstanding the negative results in the Women's Health Initiative studies.

Specifications: 

1). Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues,  but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.

Estradiol or oestradiol (American or British English usages), (oistros, literally meaning "verve or inspiration")  and -diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.

2). Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol isbiosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone). One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.[citation  Action of aromatase on this dione generates estrone, and action of adehydrogenase on this gives the title compound, 17β-estradiol.